Party Planner

Mix, manage, and mingle your way through the wildest parties in town in Party Planner, a unique new time management game from the creators of Sally's Salon!
Pepper's always been a party girl. There's nothing she loves better than helping others have a good time. When her friends suggest that Bashville is the perfect place for Pepper to start her party planning business, she packs her bags and heads for the big city.
Help Pepper put together the best parties Bashville has ever seen in 75 levels of fast-paced, frenzied fun. Pick the perfect decorations, drinks, snacks, entertainment and more. Start conversations between shy guests, show partiers to the dance floor, and stop party crashers from derailing everyone's fun. Keep everyone in a partying mood with special power-ups and hire help to make sure everything runs smoothly. Each party is a five-hour extravaganza that's sure to keep you on your toes!

Game Size 86MB

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Heileen

Heileen, cute 18 years old english girl.She has a quiet life, without any real problems. But one day, her uncle Otto, a famous english merchant, decides that it is time for a change, and forces her to follow him on a journey to the New World.During the voyage, she'll meet old and new friends and discover lots of secrets, and ultimately find what really wants for herself.Play with her this fantastic voyage along eight chapters of intriguing dialogues. Each choice you make will have a consequence in your relationship with the other crew members and will determine which one of the three different finals you'll see.

Game Size 20MB

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Mini Golf Championship

Mini Golf Championship allows you to test your skills against computer-controlled players on 3D replicas of the world's top courses. New to the game? Then learn the ins and outs in Training Mode. After you've mastered the simple controls, you can show friends and family what you've learned in Multiplayer Mode. Crisp graphics, beautifully animated greens and realistic physics will help to immerse you in the experience. And unlike the real world, you can save your progress and reload it at a later time. It's time to find out why mini golf rocks!

Game Size 21MB

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The Diet-Heart Hypothesis: Oxidized LDL, Part I

In my reading about lipoprotein particles (LDL, HDL, etc.) and how they associate with cardiac risk, I've come across three LDL-related markers that associate with risk: LDL cholesterol, LDL particle number, and LDL size/density. Is this a coincidence, or is there a reason for it?

The first marker, LDL cholesterol, is probably nothing more than a crude approximation of particle number. But LDL particle number and size/density are related to something else, that probably actually causes atherosclerosis rather than simply being associated with it: oxidized LDL (oxLDL).

oxLDL is formed when the lipids in LDL particles react with oxygen and break down. This happens specifically to the unsaturated fats in LDL, because saturated fats, by their chemical nature, are very resistant to oxidative damage. Polyunsaturated fats are much more susceptible to oxidative damage than saturated or monounsaturated fats. Linoleic acid (the omega-6 fatty acid found abundantly in industrial seed oils) is the main polyunsaturated fatty acid in LDL.

LDL is packaged with antioxidants in the liver, primarily vitamin E and coenzyme Q10 (CoQ10), to prevent its oxidation. However, the more time it spends in the blood, the more likely it is to exhaust its antioxidant store and become oxidized. Also, the smaller the LDL particle, the more likely it is to become trapped in the vessel wall and become oxidized there.

Oxidized LDL Correlates Tightly with Cardiac Risk

oxLDL has turned out to be a very sensitive marker of cardiac risk, surpassing traditional markers like LDL, HDL, and triglycerides in most studies to date. Since the discovery of sensitive assays that detect oxidized LDL drawn directly from patient blood, a number of studies have been published supporting its ability to detect atherosclerosis (plaque buildup in the arteries), heart attack risk and even the metabolic syndrome.

Holovet and colleagues published a study comparing the ability of oxLDL and a traditional risk factor assessment to detect coronary artery disease. The traditional method is called the Global Risk Factor Assessment Score (GRAS), and includes age, total cholesterol, HDL, blood pressure, diabetes and smoking status. It's similar to the commonly used Framingham risk score (which, interestingly enough, doesn't include LDL).

GRAS was able to correctly differentiate a healthy person from a person with coronary artery disease 49% of the time, while oxLDL was correct 82% of the time. Thus, oxLDL by itself was far more accurate than a whole battery of traditional cholesterol and cardiac markers. Coronary patients had more than twice the level of circulating oxLDL than the healthy comparison group.

In a large prospective study by Meisinger and colleagues, participants with high oxLDL had a 4.25 higher risk of heart attack than patients with lower oxLDL. oxLDL blew away all other blood lipid markers by nearly a factor of two. From the abstract:

Plasma oxLDL was the strongest predictor of CHD events compared with a conventional lipoprotein profile and other traditional risk factors for CHD.

Oxidized LDL Makes Sense

 Regular, non-oxidized LDL has few properties that would make it a suspect in atherosclerosis. It's just a little particle carrying cholesterol and fats from the liver to other organs. As soon as it oxidizes, however, it becomes pro-inflammatory, immunogenic, damaging to the vessel wall, and most importantly, capable of transforming immune cells called macrophages into foam cells, a major constituent of arterial plaque.

Researchers have been interested in the plaque-generating properties of oxLDL for over three decades, and quite a bit of data have accumulated. They've identified cellular receptors that allow macrophages to ingest oxLDL (CD36 and SR-A). These receptors are specific for oxLDL and do not recognize normal LDL to a significant degree. Mice whose macrophages lack either of these two receptors have the same amount of circulating LDL as normal mice, yet have 60 to 70 percent less atherosclerosis when fed a plaque-forming diet (1, 2). Shorter-term studies have not always been consistent however, suggesting that there are alternative mechanisms. I'll expand on this more later.

Another line of evidence comes from the ability of LDL-borne antioxidants to prevent atherosclerosis in animal models. The powerful synthetic antioxidant probucol greatly reduces atherosclerosis in a number of animal models. It also reduces the extremely high cholesterol rodents and herbivorous animals get when they eat a high-cholesterol "atherogenic diet", but several studies have concluded that the majority of probucol's effect is due to its antioxidant ability rather than its ability to reduce cholesterol (ref).

Vitamin E and CoQ10 are two other LDL-borne antioxidants that can reduce atherosclerosis in animal models, particularly in combination with one another. Vitamin E alone is not as effective, and in some studies totally ineffective, which is one possible explanation for the equivocal results of vitamin E cardiovascular trials in humans. The most effective combination of antioxidants is probably the one provided by a nutrient-dense diet.

In Summary

Multiple lines of evidence suggest that oxidized LDL plays a dominant role in atherosclerosis. Not only is it associated with cardiovascular risk, there's also a large body of evidence suggesting it actually directly contributes to it. 

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Build-a-lot 4: Power Source

Help an assortment of towns grow and glow by building all-new homes, shops, buildings, and, most importantly, clean sources of energy. Construct solar towers, wind farms, and even nuclear power plants to keep your cities humming and the cash flowing. Watch out for power overload! If you build too fast, you may experience a blackout and a whole neighborhood of unhappy renters. Dispatch technicians to supercharge your resources and do what ever it takes to keep the lights on. Enhance your curb appeal with fancy shops, swimming pools, boutiques, and more.
Featuring the unique gameplay of the previous Build-a-lot games, Build-a-lot 4 - Power Source also includes multiple campaigns to play, an in-depth tutorial for new players, and endless fun for everyone. Critics love the Build-a-lot series and call the latest chapter, "a top notch gaming experience." And gamers love it too! One of the most popular games of all-time, Build-a-lot has been enjoyed by millions of players and spawned numerous imitators.

Game Size 95 MB

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Have fun and feel free to leave your comments!

Recommended for free users: Use Jdownloader to increase download speed!

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3Tones

Enjoy a fun and clever Match 3 game with a musical twist! Take on a number of different musical mechanics intertwined into one exhilarating puzzle game experience! Upload your favorite music from your computer to create a totally different experience. Each song has a completely unique level, so the possibilities are endless! Use great powerups and special items as you attempt to clear each stage and progress forward.

Game Size 136MB

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Abra Academy ™: Returning Cast

There have been several strange attacks on Abra Academy™. It seems that some unknown creatures have broken into the campus and are causing havoc! The children are frightened and the monsters are creating a huge mess. Wanda and her friends have been called in to investigate the attacks and find a way to stop them.

Game Size 75MB

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